What is the Ovarian Rejuvenation (PRP) and how it may help me?

Ovarian Rejuvenation. Is it possible? How it can be done? Is PRP a solution for me?

Platelet-rich plasma (PRP) is becoming more and more popular as a non-surgical treatment option for a broad spectrum of medical disorders. How it can be used in case of infertility? How so-called ovarian rejuvenation procedure is performed? Who can use it? And is it effective at all?

We have the answers to these questions answered by fertility experts in 3on1 #IVFANSWERS :

  • Dr Inna Moroz – Fertility Specialist at ISIDA IVF Clinic
  • Dr Alejandro Aldape Arellan – senior consultant in reproductive medicine, currently Medical Director of Institut Marquès Ireland.
  • Dr Diana Obidnyak – Head of International Cooperation Department AVA Peter Clinic
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Dr Inna Moroz, ISIDA IVF, Ukraine

Answer from Dr Inna Moroz - Fertility Specialist

PRP or platelet-rich plasma therapy is using patient’s own concentrated platelets (with a high number of growth factors) into ovaries by a laparoscopy. Platelets are specific blood cells that are responsible for blood clotting out of the small injury. That’s why in the past the injection of PRP was used in medicine for acceleration of the healing process of injured tendons, muscles or joints. Now some doctors are using this method experimentally to rejuvenate the ovaries, especially in women who have premature menopause. As the experimental technique, its use, safety and effectiveness require more investigation and more clinical study. That’s why today we do not recommend to use it as a tool for infertility to our patients.

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Dr Alejandro Aldape Arellan , Institut Marquès, Spain

Answer from Dr Aldape Arellan - Medical Director

PRP, which is plasma rich in platelets for ovarian rejuvenation, is still more hope than reality.
Nowadays there is no way of fixing diminished ovarian reserve. We have been trying with several supplements, like DHEA or testosterone, with very limited success. Also the PRP hasn’t been proved to be completely safe for patients. So the bottom line is that the PRP is still experimental.

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Dr Diana Obidnyak, AVA Peter Clinic, Russia

Answer from Dr Obidnyak - Head of International Cooperation Department

Platelet-rich plasma (PRP) is becoming more and more popular as a non-surgical treatment option for a broad spectrum of medical disorders. The theory underlying this method was derived from a natural healing process. The body’s first response to tissue injury is to deliver platelets to the injured area. Platelets promote healing and attract growth factors to the site of injury. In reproductive medicine, PRP therapy is developed in different directions. The first one refers to the so-called ovarian rejuvenation for women with premature ovarian failure and patient with low ovarian reserve. During this procedure, PRP is injected into the ovary under ultrasound guidance, similarly to egg retrieval in IVF cycle. However, this type of treatment is still under investigation.
Thus, it cannot be recommended in routine practice. Nevertheless, the PRP treatment in mode of intrauterine infusions has been implemented as an inspiring strategy for patients with recurrent implantation failure and women with resistant thin endometrium.

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Three IVF experts answering the same question.

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