PGT-A After 40: Real Stories and Real Questions

For many women over 40, fertility treatment brings more than just a medical decision, it brings personal questions, emotional stakes, and hope mixed with hesitation.

One of the most powerful tools to support decision-making in this journey is PGT-A (Preimplantation Genetic Testing for Aneuploidy). It allows patients to better understand which embryos are chromosomally normal offering a clearer path to a healthy pregnancy.

Here, we share common questions and stories from real patients who turned to PGT-A after repeated losses, failed cycles, or uncertainty. Their experiences reflect the potential of genetic screening and why so many are choosing it after 40.

What Is PGT-A and Why Consider It After 40?

PGT-A is a genetic screening test performed on embryos during IVF. Its goal is to identify embryos with the correct number of chromosomes which have a higher chance of leading to a healthy pregnancy.

As women age, the risk of chromosomal abnormalities in embryos increases. By age 40, around 70% of embryos may be chromosomally abnormal. PGT-A helps avoid transferring embryos that are unlikely to implant or may lead to miscarriage.

Can PGT-A Really Make a Difference?

Yes. Many patients have gone through multiple failed IVF attempts or miscarriages before discovering that chromosomal abnormalities were the cause.

In some cases:

A woman with a history of miscarriage due to trisomy 21 (Down syndrome) used PGT-A and found the only viable embryo was euploid — helping her avoid another emotionally and physically draining loss.
Another patient had previously frozen embryos that were thawed, biopsied, refrozen, and later successfully transferred — with excellent outcomes.

Even patients over 44 with complex medical histories like endometriosis have benefited from knowing which embryos were most likely to succeed.

Is There a Risk of Losing Healthy Embryos?

This is a common concern. Studies have shown that the risk of mistakenly discarding a healthy embryo is extremely low — especially with the latest testing technologies. In rare cases, mosaic embryos (which contain both normal and abnormal cells) may be excluded, but most modern labs use advanced systems to reduce errors.

What If You’ve Already Frozen Embryos?

It’s possible to thaw, biopsy, and refreeze embryos. This is now standard practice in many labs — though it’s important the clinic has a skilled embryology team and strong protocols. The risk of embryo loss is small (about 2% per thawing cycle) when done correctly.

What About Age, Egg Quality, or Irregular Cycles?

Women in their early 40s still producing 4–5 eggs per cycle may continue trying with their own eggs — as long as they understand that success rates are lower.
For patients with irregular cycles, treatment protocols can be adjusted easily, so cycle irregularity rarely blocks the use of PGT-A.
For those using donor eggs or embryos, PGT-A can still be valuable. Studies show that 35% of donor embryos can be abnormal.

What Are Chaotic Embryos or Mosaic Embryos?

Chaotic embryos contain multiple chromosomal errors and have an extremely low chance of success.
Mosaic embryos may still implant, especially if the abnormal cells are pushed to the outer layer. Decisions about transferring these embryos are made case-by-case.

Does Embryo Grading Matter?

Grading (like “5BB”) helps embryologists evaluate the development stage and appearance of the embryo — but it doesn’t guarantee genetic normality. A high-quality embryo from a younger patient is more likely to be euploid than a perfect-looking embryo from someone over 42.

AI tools and time-lapse imaging are now helping embryologists assess embryo potential more accurately, but PGT-A remains the gold standard for identifying genetically healthy embryos.

Is There a Delay with PGT-A?

PGT-A adds about 2 to 4 weeks to the IVF process, depending on lab timing. This brief delay doesn’t affect the chances of implantation, even in older women.

Patient Case 1: One Embryo, One Chance — And It Worked

One patient had experienced a miscarriage due to trisomy 21 after a natural pregnancy. When she turned to IVF, only one of her embryos came back as euploid. Another tested with trisomy 16 — a condition that typically leads to pregnancy loss.

Thanks to PGT-A, she was able to identify the healthy embryo and avoid another painful setback.

Her story is a clear example: even just one tested embryo can make all the difference when you know it’s chromosomally healthy.

Patient Case 2 :Second Chance After Failed Transfers

One woman had several embryos frozen and initially declined genetic testing. After multiple failed transfers, she and her care team decided to biopsy the remaining embryos. The results revealed that only a few were likely to implant. This insight helped her avoid more failed cycles — and ultimately led to a successful pregnancy.

Patient Case 3: When Donor Cycles Don’t Work

At 44, one woman had already been through multiple IVF cycles with her own eggs and later with donor eggs — without success. She had two donor embryos left and a history of endometriosis requiring surgery. By using PGT-A to test the remaining embryos, she discovered which ones were most likely to succeed. This turned out to be a critical decision after years of emotional and physical challenges.

What If You’ve Already Had Multiple Failed Cycles?

For some, trying again with their own eggs — even after failures — is the right emotional and personal choice. As long as the ovaries still respond and the patient is fully informed of the lower chances, many decide to try again. And for those not ready to move to donor eggs, PGT-A can help assess whether it’s worth continuing with their own.

Final Thoughts: Real Stories, Real Decisions

Each patient above had a unique path — different diagnoses, different ages, different histories. But what they shared was a turning point: using PGT-A to guide their decisions with clarity.

Some finally saw success after years of heartbreak. Others avoided unnecessary transfers. And a few gained the peace of mind that they had done everything possible.

Table of Contents